abstract：BACKGROUND AND AIMS:Primary biliary cirrhosis (PBC) might be complicated by osteoporosis, whose etiology remains unknown but seems to be multifactorial. Prevalence rates of 30% to 60% for distal renal tubular acidosis (DRTA) have been reported in PBC patients, generally as incomplete DRTA. Although it is undisputed tha...

journal_title：Journal of gastroenterology and hepatology

authors： Farias AQ,Gonçalves LL,Cançado EL,Seguro AC,Campos SB,Abrantes-Lemos CP,Carrilho FJ

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND AIMS:We have shown previously that concentrations of stool decay-accelerating factor (DAF; CD55), a complement regulatory protein, in patients with ulcerative colitis (UC) are increased in relation to the severity of the colonic mucosal inflammation. In the present study, we evaluated the usefulness of s...

journal_title：Journal of gastroenterology and hepatology

authors： Kohno H,Mizuno M,Nasu J,Makidono C,Hiraoka S,Inaba T,Yamamoto K,Okada H,Fujita T,Shiratori Y

更新日期：2005-01-01 00:00:00

abstract：:The Steering Committee for the Prevention and Control of Infectious Diseases in Asia recently conducted a survey of primary-care physicians in Asia, which revealed that many physicians administer boosters in their clinical practice and that there is considerable variation and uncertainty among physicians regarding thi...

journal_title：Journal of gastroenterology and hepatology

authors： John TJ,Cooksley G,Steering Committee for the Prevention and Control of Infectious Diseases in Asia.

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND AIM:Hepatorenal syndrome (HRS) occurs in patients with advanced liver cirrhosis and has a poor outcome. The aim of the present study was to investigate which patients with HRS are likely to benefit from hemodialysis. METHODS:Data were collected prospectively from 30 patients with Child-Pugh C liver cirr...

journal_title：Journal of gastroenterology and hepatology

authors： Witzke O,Baumann M,Patschan D,Patschan S,Mitchell A,Treichel U,Gerken G,Philipp T,Kribben A

更新日期：2004-12-01 00:00:00

abstract：:Despite steady progress in antiviral treatment for patients with chronic hepatitis C virus(HCV), many patients still have detectable serum HCV RNA levels by the end of interferon-based treatment and are known as virological non-responders. Re-treatment of these patients not responding to previous therapy remains chall...

journal_title：Journal of gastroenterology and hepatology

authors： Poo JL,Sánchez-Avila F,Kershenobich D,García-Samper X,Gongora J,Uribe M

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND AND AIM:Interferon and ribavirin combination therapy for chronic hepatitis C produces hemolytic anemia. This study was conducted to identify the factors contributing to ribavirin-induced anemia. METHODS:Eighty-eight patients with chronic hepatitis C who received interferon-alpha-2b at a dose of 6 MU adminis...

journal_title：Journal of gastroenterology and hepatology

authors： Nomura H,Tanimoto H,Kajiwara E,Shimono J,Maruyama T,Yamashita N,Nagano M,Higashi M,Mukai T,Matsui Y,Hayashi J,Kashiwagi S,Ishibashi H

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:One-third of patients with exacerbations of ulcerative colitis (UC) require colectomy and 1% die. Although several studies have reported parameters associated with failure of medical treatment, studies using multivariate analysis of various predictors are scanty. METHODS:Demographic, clinical and laboratory...

journal_title：Journal of gastroenterology and hepatology

authors： Kumar S,Ghoshal UC,Aggarwal R,Saraswat VA,Choudhuri G

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of the study was to develop a method of quantitation of endoscopic ultrasonography (EUS) changes of chronic pancreatitis (CP). METHODS:Twenty-three patients with chronic pancreatitis by EUS were compared with nine normal subjects. Hyperechogenicity was evaluated as the size of the hyperechoi...

journal_title：Journal of gastroenterology and hepatology

authors： Irisawa A,Mishra G,Hernandez LV,Bhutani MS

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The optimal management of acute Budd-Chiari syndrome (BCS) with liver failure is controversial. Options include anticoagulation, portal systemic shunting or liver transplantation. In recent years, transjugular intrahepatic portosystemic shunts (TIPS) have been tried in place of shunt surgery. We rep...

journal_title：Journal of gastroenterology and hepatology

authors： Kavanagh PM,Roberts J,Gibney R,Malone D,Hegarty J,McCormick PA

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND AND AIM:Numerous mutations of bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) have been reported in patients with familial unconjugated hyperbilirubinemia. The UGT1A1 mutation appears to be considerably different among ethnic groups. To clarify the incidence of this gene mutation in the J...

journal_title：Journal of gastroenterology and hepatology

authors： Takeuchi K,Kobayashi Y,Tamaki S,Ishihara T,Maruo Y,Araki J,Mifuji R,Itani T,Kuroda M,Sato H,Kaito M,Adachi Y

更新日期：2004-09-01 00:00:00

abstract：:The Asia-Pacific Expert Committee on Hepatitis B Management recently reviewed the impact of hepatitis B in the region and assessed the differences and similarities observed in the practical management of the disease in individual Asia-Pacific countries. Hepatitis B is a major health concern in the Asia-Pacific region,...

journal_title：Journal of gastroenterology and hepatology

authors： Mohamed R,Desmond P,Suh DJ,Amarapurkar D,Gane E,Guangbi Y,Hou JL,Jafri W,Lai CL,Lee CH,Lee SD,Lim SG,Guan R,Phiet PH,Piratvisuth T,Sollano J,Wu JC

更新日期：2004-09-01 00:00:00

abstract：:Extraesophageal manifestations of gastroesophageal reflux disease (GERD) are essentially complications of GERD that primarily involve organs that are in proximity to the esophagus. Non-cardiac chest pain (NCCP) is an atypical manifestation of GERD, because symptoms originate in essence from the esophagus. In both atyp...

journal_title：Journal of gastroenterology and hepatology

authors： Wong WM,Fass R

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND AND AIM:Multidrug resistance associated gene product 2 (Mdr2) is believed to have a significant role in biliary cholesterol and phospholipid secretions. Both pravastatin and bezafibrate resulted in Mdr2 induction, but increased cholesterol secretion was observed only in pravastatin treatment. To explore the ...

journal_title：Journal of gastroenterology and hepatology

authors： Kamisako T,Ogawa H

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:The purpose of the present study was to investigate microvessel density (MVD), and the expression of CD44 adhesion molecule, p53 protein and c-erbB2 in gallbladder carcinoma, and their relation to histological grade and tumor invasiveness. METHODS:Immunohistochemical staining with antibodies against factor ...

journal_title：Journal of gastroenterology and hepatology

authors： Kalekou H,Miliaras D

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Depth of invasion beyond the muscularis propria (MP) by T3 rectal cancer can vary. The purpose of the present paper was to determine if depth of invasion beyond MP, as assessed by preoperative endoscopic ultrasound (EUS), can predict tumor recurrence in patients with T3 rectal tumors. METHODS:Patients with ...

journal_title：Journal of gastroenterology and hepatology

authors： Harewood GC,Kumar KS,Clain JE,Levy MJ,Nelson H

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Hypothyroidism is commonly thought to cause decreased gastric emptying but is mostly associated with autoimmune disease. In the present study the gastric emptying function of thyroid cancer patients with severe hypothyroidism of short duration was evaluated with a radionuclide solid meal gastric emptying stu...

journal_title：Journal of gastroenterology and hepatology

authors： Kao PF,Lin JD,Chiu CT,Hsu HT,See LC,Tzen KY

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND AND AIM:The mechanisms of ribavirin as an immune modulator have not been fully revealed, contrary to its clinical benefit in chronic hepatitis C. Recently, host immune defense, especially cytotoxic T lymphocytes and T helper cells, have been considered to be closely related to the pathophysiology of chronic ...

journal_title：Journal of gastroenterology and hepatology

authors： Shiina M,Kobayashi K,Satoh H,Niitsuma H,Ueno Y,Shimosegawa T

更新日期：2004-05-01 00:00:00

abstract：:The structural analysis, replicative efficiency and immunogenicity of hepatitis B virus (HBV) full-length genomes isolated from different patients or asymptomatic carriers are presented in the present review. Data indicate the importance of viral genome-based studies in elucidating the pathogenesis of HBV infections. ...

journal_title：Journal of gastroenterology and hepatology

authors： Wen YM

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The role of Helicobacter pylori infection in gastroduodenal lesions might be different between the general population and AIDS patients. The aim of the present study was to compare the prevalence of H. pylori and cytomegalovirus (CMV) infection in AIDS patients and HIV-negative controls. The impact ...

journal_title：Journal of gastroenterology and hepatology

authors： Chiu HM,Wu MS,Hung CC,Shun CT,Lin JT

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catabolic enzyme. Recent studies have focused on the immunoregulatory role of IDO in mononuclear cells. The role of IDO in hepatocellular carcinoma (HCC) cell lines and HCC patients was examined. METHODS:The expression of IDO mRNA in peripheral blood mononuc...

journal_title：Journal of gastroenterology and hepatology

authors： Ishio T,Goto S,Tahara K,Tone S,Kawano K,Kitano S

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:To elucidate the cause of possible occurrence of reflux esophagitis after Helicobacter pylori eradication, gastric and esophageal function among H. pylori infected Japanese patients were evaluated both before and after eradication therapy. METHODS:Nine H. pylori-positive patients were studied before and 6 m...

journal_title：Journal of gastroenterology and hepatology

authors： Tanaka I,Tatsumi Y,Kodama T,Kato K,Fujita S,Mitsufuji S,Kashima K

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND AND AIM:Because of its long duration, inflammatory bowel disease (IBD) causes high use of health services and high lifetime costs for medical care. The aim of the present study was to measure the costs of outpatient care in patients with IBD in a German University Hospital and to identify potentially relevan...

journal_title：Journal of gastroenterology and hepatology

authors： Ebinger M,Leidl R,Thomas S,Von Tirpitz C,Reinshagen M,Adler G,Konig HH

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of the present study was to compare the therapeutic efficacy of three different regimens in childhood chronic hepatitis B (CHB) infection. METHODS:A total of 182 children with CHB infection were prospectively allocated to three random groups. Sixty-two patients in the first group received hi...

journal_title：Journal of gastroenterology and hepatology

authors： Dikici B,Ozgenc F,Kalayci AG,Targan S,Ozkan T,Selimoglu A,Doganci T,Kansu A,Tosun S,Arslan N,Kasirga E,Bosnak M,Haspolat K,Buyukgebiz B,Aydogdu S,Girgin N,Yagci RV

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:A nitroxide radical, 4-hydroxyl-2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPOL), is directly reduced to hydroxylamine by ascorbic acid (AsA). Ascorbic acid is oxidized to dehydroascorbic acid (DHA) by ascorbic acid oxidase (AAOx), and DHA is reduced to AsA by glutathione (GSH). In the present study, in vivo and...

journal_title：Journal of gastroenterology and hepatology

authors： Tada M,Yokoyama H,Ito O,Ohya H,Ogata T

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND AIM:Products of the arachidonic acid metabolizing enzyme, 5-lipoxygenase (5-LOX), stimulate the growth of several cancer types. Inhibitors of 5-LOX and 5-LOX-activating protein (FLAP) induce apoptosis in some cancer cells. Here, the authors investigated the effect of a FLAP inhibitor, MK-886, on the inhi...

journal_title：Journal of gastroenterology and hepatology

authors： Fan XM,Tu SP,Lam SK,Wang WP,Wu J,Wong WM,Yuen MF,Lin MC,Kung HF,Wong BC

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The aim of the present study was to clarify relationship between macroscopic and microscopic features of herpes simplex esophagitis (HSE), and localization of herpes simplex virus type 1 (HSV-1)-infected cells in esophageal lesions from autopsy cases of histopathologically proven HSE. METHODS:The s...

journal_title：Journal of gastroenterology and hepatology

authors： Itoh T,Takahashi T,Kusaka K,Kawaura K,Nakagawa Y,Yamakawa J,Kanda T

更新日期：2003-12-01 00:00:00

abstract：:Alcoholic hepatitis is a potentially life-threatening complication of alcoholic abuse, typically presenting with symptoms and signs of hepatitis in the presence of an alcohol use disorder. The definitive diagnosis requires liver biopsy, but this is not generally required. The pathogenesis is uncertain, but relevant fa...

journal_title：Journal of gastroenterology and hepatology

authors： Haber PS,Warner R,Seth D,Gorrell MD,McCaughan GW

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND AND AIM:Serum cancer antigen (CA) 125 elevation has been reported in patients with liver disease, but it is poorly characterized. The present study aimed to evaluate the range of serum and ascitic CA 125 levels in patients with liver cirrhosis and to explore possible factors associated with CA 125 elevation....

journal_title：Journal of gastroenterology and hepatology

authors： Xiao WB,Liu YL

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori causes chronic gastritis, peptic ulcer, gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. Different genotypes of H. pylori are confirmed from diverse geographical areas. Its association with clinical diseases remains controversial. The aim of the present study was to i...

journal_title：Journal of gastroenterology and hepatology

authors： Perng CL,Lin HJ,Sun IC,Tseng GY,Facg

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND AND AIM:A novel virus, SEN-virus (SENV), was recently discovered. It has been reported as a candidate for a non-A-E hepatitis virus. However, much is still unknown about the clinical significance of SENV. The aim of the present study was to clarify the clinical significance of SENV in patients coinfected wit...

journal_title：Journal of gastroenterology and hepatology

authors： Lin JG,Goto T,Nakane K,Miura K,Mikami K,Ohshima S,Yoneyama K,Watanabe S

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Sodium chloride (NaCl) is a strong promoter of gastric cancer. We hypothesized that inducible nitric oxide synthase (iNOS) induced by NaCl may be involved in its promoting effects. We investigated iNOS expression by hypertonic NaCl solutions and its pathophysiological roles in the gastric mucosa of rats and ...

journal_title：Journal of gastroenterology and hepatology

authors： Tatemichi M,Ogura T,Sakurazawa N,Nagata H,Sugita M,Esumi H

更新日期：2003-09-01 00:00:00

abstract：BACKGROUNDS AND AIM:Clarithromycin (CAM)-resistant Helicobacter pylori sometimes offers serious problems with eradication by antibiotics. The aim of this study was to determine whether a probiotic can be an alternative therapy in CAM-resistant Hp infection. METHODS:The effects of Lactobacillus gasseri (strain OLL2716)...

journal_title：Journal of gastroenterology and hepatology

authors： Ushiyama A,Tanaka K,Aiba Y,Shiba T,Takagi A,Mine T,Koga Y

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Biliary disease is one of the most common causes of acute pancreatitis in adults; however, this cause and outcome in children have rarely been described in the literature. Therefore, the present study was conducted to evaluate the role of biliary disease as a cause of acute pancreatitis in children....

journal_title：Journal of gastroenterology and hepatology

authors： Choi BH,Lim YJ,Yoon CH,Kim EA,Park YS,Kim KM

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Heat-shock proteins (HSP) play an essential role in the sequestration and reparation of denatured cellular proteins. Because ethanol treatment can result in oxidative stress-induced protein damage, it is possible that expression of HSP is altered after ethanol consumption. Dose-response and time-course studi...

journal_title：Journal of gastroenterology and hepatology

authors： Rakonczay Z Jr,Boros I,Jármay K,Hegyi P,Lonovics J,Takacs T

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND AND AIM:Although rabeprazole (RPZ), a proton pump inhibitor, has been reported to have a bactericidal effect on Helicobacter pylori (H. pylori), no studies have been conducted regarding the effect of RPZ on gastric mucosal lesion formation caused by this bacterium. In the present study, we investigated the e...

journal_title：Journal of gastroenterology and hepatology

authors： Suzuki H,Miyazawa M,Nagahashi S,Sato M,Bessho M,Nagata H,Miura S,Ishii H

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND AND AIM:The attenuated antisecretory activity observed during continuous administration of ranitidine has been described as tolerance. However, it remains unclear whether a similar phenomenon occurs with other histamine H2 receptor antagonists (H2RA). We investigated whether tolerance to famotidine, a strong...

journal_title：Journal of gastroenterology and hepatology

authors： Komazawa Y,Adachi K,Mihara T,Ono M,Kawamura A,Fujishiro H,Kinoshita Y

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND AND AIM:Epimorphin is suggested to play a key role in the morphogenesis of epithelial cells. We focused on epimorphin and attempted to clarify the relationship between expression of this molecule and inflammatory bowel disease (IBD). METHODS:Colonic specimens were taken from 23 patients with ulcerative coli...

journal_title：Journal of gastroenterology and hepatology

authors： Shirasaka T,Iizuka M,Yukawa M,Hirai Y,Horie Y,Itou H,Kon-No S,Fukushima T,Watanabe S

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND AND AIM:Helicobacter pylori infection in gastric mucosa is a form of chronic active gastritis that leads to expression of inducible nitric oxide synthase in host macrophages and polymorphonuclear leukocytes. Nitric oxide produced by these cells infiltrating the gastric mucosa could damage DNA. We correlated ...

journal_title：Journal of gastroenterology and hepatology

authors： Tari A,Kodama K,Kitadai Y,Ohta M,Sumii K,Kajiyama G

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Sarcomatous hepatocellular carcinoma (HCC) has a worse prognosis than ordinary HCC. The relationship between the malignant potential of sarcomatous HCC and cell proliferation or cell adhesion is unknown. This study was undertaken to clarify this relationship. METHODS:In 21 cases of sarcomatous HCC, includin...

journal_title：Journal of gastroenterology and hepatology

authors： Nishi H,Taguchi K,Asayama Y,Aishima S,Sugimachi K,Nawata H,Tsuneyoshi M

更新日期：2003-04-01 00:00:00

abstract：:Recent autopsy studies have clarified the frequency of lymph node (LN) metastases from hepatocellular carcinoma (HCC). However, LN metastases commonly occur in advanced and poorly differentiated HCC and are very rare in small HCC. We encountered a patient with skip LN metastases from a small HCC, 10 mm in diameter. An...

journal_title：Journal of gastroenterology and hepatology

authors： Uehara K,Hasegawa H,Ogiso S,Sakamoto E,Ohira S,Igami T,Mori T

更新日期：2003-03-01 00:00:00